Sure. Logically, it makes no sense. Logically, in baseball, the American League and the National League stopped being bitter enemies decades ago, stopped using different umpires years ago, and stopped playing under different rules this year when the designated hitter became a universal element.
Logically, in football, the AFC and the NFC have never really been rivals at all, since from the start of the merger there were three teams from the old NFL (Pittsburgh, Baltimore, Cleveland) that joined the old AFL teams to strike a balanced league. Since everyone has played under one shield, since 1970, there have never been any notable decrees of conference pride.
So yes, every once in a while, when the idea is floated that MLB and the NFL should radically realign, there are few rational explanations to offer up why that shouldn’t happen. The NBA and NHL have merrily divided their two conferences strictly along geographic lines, with the Mississippi River unofficially providing the dividing line.
And, with apologies to Sam Cooke, geography has its place.
But since when are sports devoted to the practice of logic? Sports inspires grown men (and women) to paint their faces in team colors. Sports require that during a rally, you stay seated in your chair no matter how fiercely nature calls. Sports keeps you up until crazy hours of the morning on a work night because your team is playing on the coast.